High Capacity Positively Charged PES Capsule Filter (Pharmaceutical Grade) – HPPC

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The HPPC Filter is constructed with a high-capacity, dual-layer, positively charged PES membrane and is engineered for sterilizing-grade filtration in high particle load applications. Designed for pharmaceutical and biopharmaceutical processes, HPPC filters provide absolute bacteria retention while also removing negatively charged contaminants such as endotoxins, viruses, and cell fragments. With a built-in prefilter layer and low protein binding characteristics, these filters deliver high flow, extended service life, and consistent performance from lab scale to full production.

Key Features:

• Dual-Layer PES Membrane: High-capacity prefilter with asymmetric final membrane
• Positively Charged Media: Enhances removal of endotoxins and biological contaminants
• Sterilizing-Grade Filtration: Validated for absolute bacteria retention
• Low Protein Binding: Ideal for biologics, proteins, and preservative-containing fluids
• High Flow & Throughput: Designed for high particle load applications
• Integrity Tested: 100% tested and flushed to reduce extractables

Performance Parameters:

• Max Operating Temp (Water): 180 °F at 30 psid (cartridge), 110 °F at 30 psid (capsule)
• Forward Pressure Limit: 80 psid at 68 °F
• Reverse Pressure Limit: 50 psid at 68 °F
• Recommended Changeout: 35 psid
• Max Operating Pressure (Capsule): 80 psi liquid / 60 psi gas at 68 °F

Sterilization & Cleaning:

• Autoclave: 250 °F (121 °C), 30 min, 25+ cycles
• Inline Steam: 275 °F (135 °C), 30 min, 25+ cycles (cartridge)
• Hot Water: 194 °F (90 °C), 30 min, max 3 psid forward
• Compatible with hydrogen peroxide, peracetic acid, sodium hypochlorite, and other standard sanitants

Filtration Area (Nominal):

• 2" – 0.9 ft² (0.08 m²)
• 5" – 2.5 ft² (0.23 m²)
• 10" – 5.4 ft² (0.50 m²)
• 20" – 10.8 ft² (1.00 m²)
• 30" – 16.2 ft² (1.50 m²)
• 40" – 21.6 ft² (2.00 m²)

Construction Materials:

• Filtration Media: Dual-layer positively charged PES membrane with polyester support prefilter
• Support Cage & Core: Polypropylene
• Sealing Method: Thermal bonding
• O-Rings (Cartridges only): Buna, Viton® (FKM), EPDM, Silicone, FEP-encapsulated options

Validated Microbial Retention:

• 0.03 µm: Acholeplasma laidlawii
• 0.10 µm: Brevundimonas diminuta
• 0.10M µm: Acholeplasma laidlawii
• 0.22 µm: Brevundimonas diminuta (sterilizing grade)
• 0.45 µm: Serratia marcescens

Typical Applications:

• Process water
• Water for Injection (WFI)
• Biopharmaceutical fluids
• High particle load solutions
• Protein and preservative-containing products