10 Inch Charged Nylon Membrane Pharmaceutical Grade Filter Capsule (PNCXPGC)

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The PNCX Capsule Filter utilizes a positively charged Nylon 6,6 membrane to provide dual-function sterile filtration and endotoxin removal for aqueous and nonaqueous fluids. With validated bacterial retention and >2-log endotoxin reduction, PNCX capsules are ideal for bioprocessing and pharmaceutical applications requiring low bioburden and contaminant control.

PNCX capsules are hydrophilic, chemically compatible, and manufactured to deliver high flow rates, reliable performance, and low extractables across a wide range of fluid types.

Key Features:

• Positively Charged Nylon 6,6 Membrane: Removes negatively charged endotoxins and microorganisms
• Validated Sterilizing Grade: 0.10 μm and 0.22 μm meet FDA standards
• Low Extractables: Maintains purity in critical fluid streams
• Endotoxin Reduction: >2-log removal typical under standard conditions
• TOC & Conductivity Compliant: Conforms with USP <643> and <645> after flushing

Performance Parameters:

• Max Operating Temp (Water): 110 °F at 30 psid (43 °C at 2.07 bar)
• Forward Pressure Limit: 80 psid at 68 °F
• Reverse Pressure Limit: 50 psid at 68 °F
• Recommended Changeout: 35 psid

Sterilization & Cleaning:

• Autoclave: 250 °F (121 °C), 30 min, 25+ cycles
• Inline Steam: 275 °F (135 °C), 30 min
• Hot Water: 194 °F (90 °C), 30 min, max 3 psid forward
• Compatible with H₂O₂, peracetic acid, bleach, etc.

Filtration Area (Nominal):

• 2" – 1.2 ft² (0.11 m²)
• 5" – 3.3 ft² (0.31 m²)
• 10" – 7.0 ft² (0.65 m²)
• 20" – 14.0 ft² (1.30 m²)
• 30" – 21.0 ft² (1.95 m²)
• 40" – 28.0 ft² (2.60 m²)

Construction Materials:

• Filtration Media: Positively charged Nylon 6,6 membrane with polyester support
• Capsule Housing: Polypropylene
• Sealing Method: Thermal bonding

Validated Microbial Retention:

• 0.10 μm & 0.22 μm: Brevundimonas diminuta
• 0.45 μm: Serratia marcescens
• 0.65 μm: Saccharomyces cerevisiae

Typical Applications:

• Process Water
• Water for Injection (WFI)
• Sterile Filtration
• Endotoxin Removal